Dr.Natesan has specialization in the field of virology and cell biology, and has expertise in the field of genomics, advanced microscopic imaging, and flow cytometry. He has finished his postdoctoral fellowship in the Department of Neurology at The Johns Hopkins University in USA, where he has extensively worked on the genome sequencing of HIV for virus trafficking between different tissue compartments to understand the evolution of virus within a HIV infected patient over a period of time. The essential goal of the project was to identify the cellular and tissue that act as reservoir for HIV during chronic infection period by applying the genomics. Dr.Natesan also has expertise in the advanced confocal imaging and flow cytometry. He has characterized the blood and bone marrow cells, lymph node biopsy, and cerebrospinal fluid of normal as well as HIV infected patients using these techniques very extensively. After the completion of his fellowship, he joined the University of Maryland School of Medicine as Assistant professor in infectious diseases, where he extensively studied the human cells by flow cytometry and confocal microscopy.  He also worked on humanized mice model by engrafting human cells in mice and understating their in vivo developmental potential by flow cytometry and confocal microscopy. He also studied the phenotypic and functional nature of HTLV-transformed T cell lines. His expertise in the field of cell biology and advanced microscopic imaging and flow cytometry lead to the discovery of a novel cell type called Nurse Macrophage, a specialized cell type play crucial role in T-cell generation by his group. He was teaching a course on Genomics and proteomics in Nirma University as a visiting professor. He has published more than 35 research and review papers, 6 book chapters, and presented research papers in various conferences. He has spent more than 8 years in research and teaching activities in two top universities in USA.